Studies that I recently discovered to be particularly interesting and useful:


-Dean O, Giorlando F, Berk M. N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. J Psychiatry Neurosci. 2011;36(2):78–86. doi:10.1503/jpn.100057

-Ellegaard PK, Licht RW, Poulsen HE, et al. Add-on treatment with N-acetylcysteine for bipolar depression: a 24-week randomized double-blind parallel group placebo-controlled multicentre trial (NACOS-study protocol). Int J Bipolar Disord. 2018;6(1):11. Published 2018 Apr 5. doi:10.1186/s40345-018-0117-9

-Probiotic Treatment in Individuals with Euthymic Bipolar Disorder: A Pilot-Study on Clinical Changes and Compliance.Neuropsychobiology. 2018 Oct 19:1-9. doi: 10.1159/000493867. Reininghaus EZ, et al.

-Adjunctive probiotic microorganisms to prevent rehospitalization in patients with acute mania: A randomized controlled trial.Bipolar Disord. 2018 Nov;20(7):614-621. doi: 10.1111/bdi.12652. Epub 2018 Apr 25.Dickerson F1, et al.

-Chakrabarti S. Thyroid functions and bipolar affective disorder. J Thyroid Res. 2011;2011:306367. doi:10.4061/2011/306367

-Romo‐Nava, F et al.  Melatonin attenuates antipsychotic metabolic effects: an eight‐week randomized, double‐blind, parallel‐group, placebo‐controlled clinical trial. Bipolar Disord 2014: 16: 410– 421


-Inhaled isopropyl alcohol for nausea and vomiting in the emergency department

Adrienne J. Lindblad, Rhonda Ting, Kevin Harris. Canadian Family Physician Aug 2018, 64 (8) 580;


-HINTS to diagnose stroke in the acute vestibular syndrome: three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging. Stroke. 2009 Nov;40(11):3504-10.Kattah JC1, Talkad AVWang DZHsieh YHNewman-Toker DE.

Favourite medical podcasts that I am currently listening to:

-Emergency Medicine Cases (EM Cases)

- Core IM (internal medicine)


- The Curbsiders (internal medicine)

- Primary Care Reviews and Perspectives

- EMCrit (emergency medicine)

- REBEL Cast (emergency medicine)

Some of my projects (please feel free to reach out if you happen to share any of my interests):

The Economic and Clinical Utility of Fecal Calprotectin Use by Family Physicians:


Dr. Eric M. Sigmund
 MD, CCFP (Family Practice)
BSc (Theoretical Physics/Mathematics)

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